光学相干断层扫描仪在多发性硬化患者中的初步应用

摘要

Objective To evaluate the retinal nerve fiber layer (RNFL) thickness and macular fovea thickness/volume in multiple sclerosis patients and healthy individuals with optical coherence tomography(OCT). Methods Thirty consecutive multi-ple sclerosis patients(60 eyes) and 30 healthy individuals(60 eyes) were recruited in this prospective study. Multiple sclerosis pa-tients were classified as MS patients with a history of optic neuritis (41 eyes, MS- ON group) and MS patients without history of optic neuritis (19 eyes, MS- NON group). Comprehensive ophthalmic examinations, including RNFL thickness and macular fovea thickness/volume were performed using Humphrey OCT. Mean values for the thickness of the peripapil ary RNFL and macular volume were calculated. Results The RNFL thicknesses in each quadrant in MS patients were al thinner than those in healthy controls(P<0.05). The average macular thickness and macular volume were both thinner in MS patients. The RNFL thickness and macular fovea thickness/volume in each quadrant were al thicker in eyes without optic neuritis than those in eyes with optic neu-ritis. Conclusion OCT measurements can effectively identify the nerve changes in MS patients, which is of value in diagnosis of MS.%目的：利用光学相干断层扫描仪（OCT）评估多发性硬化（MS）患者与正常人眼视网膜神经纤维层（RNFL）厚度和黄斑中心凹厚度及体积的差异，评估OCT监测MS患者病程中轴突缺失的意义。方法选取MS患者30例（60眼），根据有无视神经炎（ON）发作史分为MS- ON组（41眼）和MS- NON组（19眼），同时选择年龄和性别相匹配的健康体检者30例（60眼）为对照组。对3组受试者均进行详细的眼科检查，并使用OCT测定RNFL厚度和黄斑参数。采用单因素方差分析对3组的RNFL厚度、黄斑中心凹厚度和体积的差异进行分析。结果两组MS患者的RNFL厚度和黄斑参数与对照组均有统计学差异，MS- ON组和MS- NON组之间的RNFL厚度和黄斑参数也有差异（均P＜0.05）。结论 OCT可作为MS诊断的辅助检查手段。