重度子痫前期孕妇血清前白蛋白 胆碱酯酶分析

摘要

Objective To study the changes and clinical value of serum prealbumin (PA) and cholinesterase (ChE) in patients with severe preeclampsia. Methods From Jan 2015 to Oct 2015 90 patients with severe preeclampsia were recruited as the observation group,and 70 healthy pregnant women with same age and same stage of pregnancy were selected as the control group,their blood pressures were normal and they had no obstetrical complications.Serum Alanine aminotransferase(ALT),Aspartate aminotransferase(AST),prealbumin (PA) and cholinesterase (ChE) levels were measured,the differences of the above indicators were compared.Results There were no significant differences in AST and ALT between the two groups(P>0.05),and there were statistically differences in PA and ChE between the two groups (P<0.05). Conclusion Severe preeclampsia often associated with abnormal liver function,abnormal changes in PA and ChE precede the changes in ALT and AST.PA and ChE should be as an early predictor and should be paid more attention.%目的：探讨重度子痫前期孕妇血清前白蛋白（PA）、胆碱酯酶（ChE）的水平变化及临床价值。方法选择2015年1月至10月重度子痫前期孕妇90例为观察组，另选择同期孕周和年龄与重度子痫前期组相匹配的血压正常、无产科合并症及并发症的健康孕妇70例为对照组，常规检测两组孕妇入院时ALT、AST、PA、ChE的水平，比较两组孕妇上述指标的差异。结果观察组孕妇入院时ALT、AST分别为：（16.53±5.00）U/L、（18.40±4.50）U/L，对照组孕妇ALT、AST分别为：（15.62±6.17）U/L、（17.07±6.60）U/L，两组比较ALT、AST差异无统计学意义（P>0.05）；观察组孕妇入院时PA、ChE分别为：（190.08±39.22）mg/L、（5583.40±1296.04）U/L，对照组分别：（234.90±38.67）mg/L、（6310.66±1175.11）U/L，两组比较差异有统计学意义（P<0.05）。结论重度子痫前期孕妇常伴随肝功能的异常改变，PA、ChE的异常变化先于ALT、AST，应作为一个早期预测指标加以重视，如发现异常改变应密切随访、及时复查。