不同授精方式对控制性促排卵周期中卵巢低反应患者助孕结局的影响

摘要

目的：探讨不同授精方式对控制性促排卵周期中卵巢低反应患者助孕结局的影响。方法回顾性分析217例首次接受控制性卵巢刺激后卵巢低反应周期患者的临床资料，严格按中心的ICSI适应证SOP执行，按照治疗方法分为两组，分别为体外受精-胚胎移植（IVF）组107例和卵胞浆内单精子注射（ICSI）组110例。观察记录两组的妊娠率及着床率、受精率、流产情况，并进行比较。结果 IVF组的妊娠率及着床率均高于ICSI组，但差异无统计学意义（P>0.05），2组均未出现流产现象。结论利用不同的授精方式对控制性促排卵周期中卵巢低反应患者进行人工助孕可以产生相似的结局。这就表明ICSI技术在治疗由严重男性因素引起的不育症可以与IVF治疗主要由女方不育因素引起的不育症方面取得类似的效果。%Objective To investigate the effects of different insemination methods on the pregnancy outcome of the patients with low response to ovarian response during controlled ovarian stimulation cycle. Methods A retrospective analysis on periodic clinical data were performed in 217 cases receiving the first controlled ovarian stimulation of poor ovarian response of our hospital from Dec, 2013 to Dec, 2014,strictly according to the center of the ICSI to certificate the SOP execution. According to the method of treatment is divided into two groups,respectively,for in vitro fertilization and embryo transfer (IVF) group(n=107) and intracytoplasmic single sperm injection(ICSI) group 110 cases. The pregnancy rate, implantation rate,fertilization rate and abortion rate of the two groups were observed and recorded. Results the pregnancy rate and implantation rate of IVF group were higher than that of ICSI group,but the difference was not statistically significant(P>0.05). There was no abortion in the 2 groups. Conclusion Using different methods of insemination in the control of ovulation induction cycle in patients with low response to artificial insemination can produce a similar outcome. This shows that the ICSI technology in the treatment of infertility caused by severe male factors can be treated with IVF mainly by the woman infertility caused by infertility aspects to achieve similar Results.