Objective To evaluate the efficacy of Jianpi Huayu Decoction in the prevention of first bleeding of gastroesophageal varices. Methods 60 patients with cirrhosis complicated with gastroesophageal varices were divided into 2 groups. The control group was treated with propranolol,and the observation group was treated with Jianpi Huayu Decoction and propranolol. The course of treatment was 6 months. The incidence of the first bleeding of gastroesophageal varices,the degree of the gastroesophageal varices under gastroscope and the grade of hepatic function in Child-pugh were compared between the two groups. Results The incidence of first bleeding in the observation group was lower than that in the control group (P<0.05). The degree of the gastroesophageal varices under gastroscope and the grade of hepatic function in Child-pugh in the observation group were significantly improved compared with the control group(P<0.05). Conclusion Jianpi Huayu decoction is effective and safe in the prevention of first bleeding of gastroesophageal varices.%目的 评价健脾柔肝化瘀汤辅助预防食管胃底静脉曲张首次出血的疗效.方法 肝硬化合并食管胃底静脉曲张患者60例,分为2组,对照组口服心得安,观察组在对照组基础上加健脾柔肝化瘀汤口服,疗程均为6个月.比较两组治疗期间首次消化道出血发生率、胃镜下食管胃底静脉曲张及肝功能Child-pugh分级情况.结果 观察组首次出血发生率明显低于对照组(P<0.05).观察组肝功能及食管胃底静脉曲张Grade分级较对照组明显改善(P<0.05).结论 健脾柔肝化瘀汤辅助预防食管胃底静脉曲张首次出血效果显著,且安全可靠.
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