LEEP与CKC治疗宫颈上皮内瘤变的效果及妊娠结局分析

摘要

目的 探讨宫颈电环切除术(LEEP)及冷刀锥切术(CKC)治疗宫颈上皮内瘤变(CIN)临床效果及对妊娠结局的影响.方法 回顾性分析2014年1月至2015年1月133例诊断为CIN Ⅰ～Ⅲ级患者的临床资料,其中行LEEP术患者75例,行CKC术患者58例,观察两组治疗效果及妊娠结局等.结果 LEEP组手术时间、出血量明显少于CKC组,差异有统计学意义(P＜0.05);两组并发症发生率差异无统计学意义(P＞0.05);两组术前术后病理一致性、浸润癌、切缘阳性、复发情况比较,差异无统计学意义(P＞0.05);两组妊娠、异位妊娠、流产、早产、剖宫产、低体重初生儿等发生率比较,差异无统计学意义(P＞0.05).结论 LEEP和CKC是常用的治疗CIN的有效方法,两种手术方式对妊娠结局影响无差异,但LEEP具有操作简便、手术时间短、出血量少、并发症少、费用低等优势,值得在临床上推广应用.%Objective To investigate the clinical effect and influence on pregnancy outcome of cervical loop electrosurgical excision procedure (LEEP) and cold knife conization (CKC) in the treatment of cervical intraepithelial neoplasia (CIN).Methods The clinical data of 133 patients diagnosed with grade CIN-Ⅲ from January 2014 to January 2015 were analyzed retrospectively.Among them, 75 patients underwent LEEP and 58 patients underwent CKC, and the therapeutic effect and pregnancy outcome of the two groups were observed.Results The operation time and the amount of bleeding in group LEEP were significantly less than those in group CKC, the difference was statistically significant (P＜0.05).There was no significant difference in the incidence of complications between the two groups (P＞0.05).The pathological consistency, invasive carcinoma,positive margin and recurrence of the two groups were not statistically significant (P＞0.05).There was no significant difference between the two groups in the incidence of pregnancy, ectopic pregnancy, abortion, premature delivery, cesarean section, low birth weight, newborn infants (P＞0.05).Conclusion LEEP and CKC are effective methods for the treatment of CIN, and there is no difference between the two operation methods on the pregnancy outcome.But LEEP has the advantages of simple operation, short operation time, less bleeding, less complications and lower cost.And this therapy deserves further popularization and application.