衢州市不同孕期孕妇甲状腺功能指标参考范围初建及探讨

摘要

目的 研究符合浙江省衢州市情况的妊娠期甲状腺功能指标参考范围和变化趋势,为临床提供更准确并符合本地情况的实验数据.方法 选择2014年3月至2015年9月建卡孕检和产科待产的本市常住妊娠妇女,入选妊娠妇女为T1期妊娠1~12周(妊娠早期)、T2期妊娠13~27周(妊娠中期)、T3期妊娠28~40周(妊娠晚期)[各组均为(整4周±1周)],每阶段妊娠妇女120例,共360例.测定其TSH、TT4、FT4和TPOAb指标,确定本地区妊娠不同期TSH、TT4、FT4的参考范围.结果 TSH的参考范围:T10.12~4.37mIU/L,T20.14~4.51mIU/L,T30.39~5.69mIU/L;FT4的参考范围:T111.27~20.66pmol/L,T29.29~17.59pmol/L,T38.49~14.82pmol/L;FT3的参考范围:T13.72~5.57pmol/L,T23.18~5.13pmol/L,T32.73~4.82pmol/L.结论 建立衢州市健康孕妇血清甲状腺功能指标正常参考范围,有助于地区妊娠期甲状腺疾病的筛查诊治.%Objective To establish a trimester-specific reference for thyroid hormone in pregnant women from Quzhou of ZheJiang. Methods From March 2014 to September,360 cases of pregnant women in Quzhou Meternity and Child Health Care Hospital were chosen and divided into 3 groups by pregnancy stage:T1:1 week to 12 week;T2:13 week to 27 week;T3:28 week to 40 week.TSH,TT4 and FT4 were meassured with immunochemiluminescent assay under the same laboratory conditions. Results TSH:T10.12~4.37mIU/L,T20.14~4.51mIU/L, T30.39~5.69mIU/L;FT4:T111.27~20.66pmol/L,T29.29~17.59pmol/L,T38.49~14.82pmol/L;FT3:T13.72~5.57pmol/L,T23.18~5.13pmol/L,T32.73~4.82pmol/L. Conclusions To establish the normal reference range of serum thyroid function indexes of healthy pregnant women in Quzhou is very important for the diagnosis and treatment of thyroid diseases in the area.