中性粒细胞/淋巴细胞比值在高血压病患者左室舒张功能障碍时的变化及价值

摘要

Objective To evaluate the relationship between neutrophil/lymphocyte ratio (NLR) and left ventricular diastolic dysfunction of hypertensive patients. Methods 50 hypertensive patients with any grade of diastolic dysfunction were selected as study group and 50 hypertensive patients without diastolic dysfunction detected by echocardiography were compared as control group. And then NLR level for each group was detected and calculated. Finally, all hypertensive patients with diastolic dysfunction were graded according to E/A and E/Ea. Results The patients with diastolic dysfunction had significantly higher values of NLR (2.0± 0.7 VS. 1.7±0.5,P=0.006). The patients with higher grade of diastolic dysfunction had higher values of NLR. NLR level was positively correlated with E/A and E/Ea. Conclusion Patients with diastolic dysfunction had higher values of NLR compared to those without diastolic dysfunction. Furthermore higher grades of diastolic dysfunction were associated with higher levels of NLR. Therefore, NLR has a certain prognostic values in diastolic dysfunction of hypertensive patients.%目的 探讨中性粒细胞/淋巴细胞比值(neutrophil/lymphocyte ratio,NLR)是否与高血压病患者左室舒张功能障碍(left ventricular diastolic dysfunction,LVDD)以及其严重程度存在联系.方法 选取50名经超声证实存在LVDD的高血压病患者为LVDD组,另外选取50名无LVDD的高血压病患者为对照组.检测并计算NLR,并依据E/A以及E/Ea将LVDD患者的严重程度进行分级.结果 LVDD组患者的NLR水平显著高于对照组(2.0±0.7 VS. 1.7±0.5,P=0.006);重度LVDD患者的NLR水平显著高于中度以及轻度LVDD患者;NLR与E/A(r=0.735, P<0.001)以及E/Ea(r=0.670,P<0.001)均呈正相关.结论 LVDD患者的NLR水平显著升高,且随着LVDD的严重程度增加,NLR与E/A以及E/Ea呈正相关,因此NLR对LVDD的发生及发展有一定预测价值.