Logistic回归方程对阿苯达唑两种剂型药物治疗囊性包虫病的临床疗效评价

摘要

目的：应用Logistic回归的方法评价阿苯达唑两种剂型药物治疗囊性包虫病的临床疗效。方法回顾性分析我院自1998～2008年十年收治的阿苯达唑脂质体和阿苯达唑片治疗的共269例囊性包虫病患者的临床随访资料，通过一定的纳入及排除标准，入组病例218例。依据随访记录的可能对临床疗效产生影响的各项指标，应用SPSS13.0及PEMS3.1医学统计软件包对各项指标进行分析并建立Lo-gistic回归方程深入分析。结果影像学疗效结果评价显示阿苯达唑脂质体组与阿苯达唑片剂组比较，3个月总有效率差异有显著统计学意义（χ2=19.581，P=0.00001），将两个治疗组作为疗效的影响因素引入Logistic回归方程分析结果也显示，两个治疗组比较总有效率差异有统计学意义（χ2=20.806，P＜0.001, OR＜1，95%CI：0.119～0.428）。结论阿苯达唑脂质体及阿苯达唑片剂均是有效的抗包虫药物，Logistic回归方程的结果结合影像学疗效评价显示阿苯达唑脂质体疗效优于阿苯达唑片剂。%Objective To evaluate the clinical effect of liposomal albendazole and tablet-albendazole in treating cystic echinococcosis (CE) by using logistic regression equation. Methods Reviewing clinical data for 269 cases of cystic echinococcosis treated by liposomal albendazole and tablet-albendazole in our hospital between 1998 and 2008,218 cases were included by into and out of standard. Based on indictors which could influence clinical effect, by using SPSS13.0 and PEMS3.1 statistical package of medicine, logistic regression equation were established to analyze the date. Results In short-term effect of evaluation (3 months), the effect of group liposomal albendazole was better than group tablet-albendazole based on images. Same result, Logistic regression analysis showed remarkable statistical difference in general effective rate between the group liposomal albendazole and tablet-albendazole (χ2=20.806,P<0.001,OR<1,95%CI:0.119~0.428), when the two group were introduced logistic regression equation as influencing factors for effect. Conclusions Liposomal albendazole and tablet-albendazole are also effective medicine for cystic echinococcosis, the effect of liposomal albendazole is better than tablet-albendazole based on analysis of logistic regression equation and evaluation of images.