We performed a pilot study to assess the significance of modest, asymptomatic, elevated serum cardiac markers- troponin T(TnT) and creatinine kinase- MB(CK- MB)- 18- 24 h following successful elective percutaneous coronary intervention(PCI)and to explore their relationship with changes in aerobic exercise capacity, as measured by peak oxygen consumption(VO2), 6 weeks following the procedure. Twenty-three patients with single-vessel disease and chronic angina performed an incremental cardiopulmonary exercise test before and 6 weeks after successful uncomplicated PCI. A venous blood sample was taken at rest before PCI and 18-24 h after the procedure. Successful PCI resulted in a trend towards an increased peak VO2 [21. 62 ±0. 64(pre) vs. 23. 03±0. 75 ml/kg/min(post), p = 0. 07; mean ± SEM] . There was a significant increase [median(IQR) ] in TnT, from 0. 00(0. 00) μg/l at baseline increasing to 0.02(0.03) μg/l at 18-24 h, p = 0. 002. CK-MB levels showed no significant difference. In the group of 15/23(65%) patients with an elevation in serum TnT( FF>> 0. 01 μg/l), 18-24 h after successful PCI, there was no significant increase in peak VO2 [23. 31 ±0. 96(pre)vs. 23. 89 ± 1. 09 ml/kg/min(post), p=0. 57] . In 8(35% ) patients with no rise in TnT at 18 - 24 h, a significant increase in peak VO2 was observed following successful PCI[23. 10 ±0. 91 (pre) vs. 25. 09 ± 0. 75 ml/ kg/min(post), p =0. 02]. Although 7 of these 8 patients increased their peak VO2, the absence of a TnT rise at 18-24 h was not significantly associated with an increase in peak VO2 following successful PCI(p =0. 18). To confirm these interesting initial results and investigate the relationship of serum cardiac markers following successful PCI and subsequent exercise capacity, further studies are required.
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