To report visual outcomes after peeling of the internal limiting membrane (ILM ) using a brief application of low dose indocyanine green (ICG) for macular hole repair. Prospective, nonrandomized interventional case series. A consecutive se ries of 16 eyes of 14 patients with full thickness macular hole underwent vitre ctomy and peeling of the ILM with an intravitreal application of 0.05%ICG for l ess than 10 seconds. The ILM could be removed uneventfully in 5 of 16 cases afte r a single ICG application and in 11 cases after a second ICG application. The m acular hole was closed in 15 (93.7%) of 16 cases after a single surgery and in one case after a repeat surgery, as evaluated by optical coherence tomography. A significant visual acuity improvement was achieved as the mean logarithm of the minimum angle of resolution was from 0.600 preoperatively (equivalent to approx imately 5/20 in the conventional 20 foot numerator form) to 0.213 (12/20) at the end of follow up (P < .0001). None of the cases developed peripheral visual fi eld defect. Ophthalmoscopies or optic coherence tomographic images did not revea l any disruption at the level of the retinal pigment epithelium. A brief intravi treal application of low dose ICG may provide a safe ILM peeling in vitreomacula r surgeries.
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