PURPOSE. To investigate the effect of variations in blood glucose level on the multifocal electroretinogram (mfERG) in patients with type 1 diabetes without r etinopathy. METHODS. Fourteen patients were clamped sequentially and in random o rder at 5 and 15 mM blood glucose for 75 minutes on the same day. mfERG was reco rded in one eye at each level of blood glucose level. RESULTS. Compared to eugly cemia (5 mM), hyperglycemia was associated with an overall decrease in the impli cit times and an increase in the amplitudes of the multifocal ERG. The effect of hyperglycemia on implicit time reached statistical significance for the summed first positive (P1) and second negative component (N2) of the first-order kerne l (P = 0.0020 and 0.0005, respectively) and all components of the second-order kernel (P=0.014, 0.0037, and 0034, respectively). These changes in the mfERG dem onstrated no significant variation in relation to retinal location or long-term blood glucose level. CONCLUSIONS. Steady- state hyperglycemia induced shorter first-and second-order kernel implicit t imes in patients with type 1 diabetes without retinopathy. The effects of hyperg lycemia were not significant with retinal location. These results support the hy pothesis that hyperglycemia accelerates retinal metabolism.
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