Intrauterine insemination (IUI) offers a less invasive, less timeconsuming and less expensive method of infertility treatment compared to invitro fertilisation. 1005 IUI cycles in 349 women were analysed retrospectively. In 29.2%of these women at least one pregnancy was achieved by IUI. The pregnancy rate per cycle was 9.4-11.7%in the first 4 cycles and decreased thereafter. The female age influenced the chance of conceiving (13.0, 10.6 and 6.8%with a female age of ≤30, 31-35 and 36-40 years, respectively) as well as the cause of infertility. The duration of infertility correlated with the pregnancy rate, but without reaching statistical significance. The pregnancy rate also decreased with a spermatozoa concentration <20 million/ml, with <5%of normal morphology and with <50%motile spermatozoa. The percentage of nonpregnant patients who discontinued therapy early was only 4.8-16.0%per cycle. However the percentage of patients who switched to an ICSI therapy increased from 9.9%after the first cycle to 37.1 %after the sixth cycle.
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