Objective. Invasive cervical cancer (ICC) is one of the most common malignant diseases among women, representing almost 10% of all the cancers in the female population. The aim of this study was to explore the association of the CCR2- 64I polymorphism with the risk of developing invasive cervical cancer (ICC) from squamous intraepithelial lesions (SILs)- . Methods. DNA samples were extracted from peripheral blood cells of 109 patients with squamous intraepithelial lesions (28 low- grade and 81 high- grade cases) and 217 patients with ICC. The CCR2- 64I polymorphism was analyzed through polymerase chain reaction (PCR)- restriction fragment length polymorphism (RFLP) (BseJI). The odds ratio (OR) and its 95% confidence interval (CI) were calculated as a measure of the association between CCR2- 64I genotypes and cervical cancer risk. Results. The frequency of the G/A genotype was significantly higher in SIL patients (n = 109) than ICC patients (n = 217) (P = 0.005; OR = 0.42; 95% CI: 0.22- 0.83). Furthermore, no association was found when we analyzed the influence of the A allele in the progression from low- grade SIL (LSIL) to high- grade SIL (HSIL) (OR = 1.05; 95% CI = 0.370- 2.98; P = 0.930), but a statistically significant association was found in the progression from high- grade SIL to ICC (OR = 0.435; 95% CI = 0.222- 0.854; P = 0.014). Conclusion. These findings suggest that CCR2- 64I polymorphism might have a protective role in the evolution from high-grade SIL to ICC.
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