cqvip:Hereditary mixed polyposis syndrome (HMPS), characterized by hyperplastic, ju venile, admixed, serrated adenomas and eventually colorectal cancer, is managed by repeated polypectomy and surgery. We determined if HMPS polyps express cycloo xygenase- 2 (COX- 2). Nineteen recent HMPS polyps, from five family members, w ere stained for COX- 2. Polyps’ epithelium and stroma and comparison tissues (normal colonie mucosa [9], sporadic juvenile polyps [18], colorectal cancers [3 ]) were quantified for COX- 2 by: area of staining (0- 3) x intensity (0- 3). Epithelial, stromal, and total scores were evaluated in relationship to histolo gy and dysplasia. HMPS polyps COX- 2 mean epithelial (5.0 ± 3.0), stromal (6. 9 ± 1.9), and total (11.8 ± 4.6) scores were significantly higher (P < 0.01) than sporadic juvenile polyps (0.6 ± 0.7, 3.1 ± 2.2, and 3.6 ± 2.2 respec tively), while colorectal cancer scored 9, 9, and 18. There was a positive assoc iation (P < 0.01) among histology, degree of dysplasia, and COX- 2 expression. COX- 2 expression in HMPS polyps and its association with dysplasia suggest tha t chemoprevention might be a useful adjunct therapy.
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