Objective to investigate clinical effect of treatment of moderate to severe cancer pain by oxycodone hydrochlo-ride and morphine sulfate. Methods 80 patients with moderate to severe cancer pain in our hospital from March 2009 to March 2012 were divided into the observation group(40),treated by oxycodone hydrochloride and the control group(40),treated by morphine sulfate.the pain and quality of life of two groups were compared before and after treatment . Results after 14d treat-ment ,the remarkable efficiency and the total efficiency of observation group were 95% and 97.5% and the control group were 92.5% and 97.5%. there were no significant differences between them(P>0.05).the adverse reactions of the two group were constipation,dizziness,nausea,vomiting,drowsiness and so on. Conclusion the analgesic clinical effects of the oxycodone hydrochloride and morphine sulfate in the treatment of moderate to severe cancer pain are significant and the adverse reactions of the two drugs are small ,but the oxycodone hydrochloride have less constipation occurred and can be used as the drug of choice in the treatment of severe cancer pain .% 目的观察分析盐酸羟考酮控释片与硫酸吗啡缓释片对中重度癌痛患者治疗效果以及生活质量的影响.方法将2009年3月-2012年3月间在我院进行治疗的80例中重度癌痛患者,采用随机分组法分为观察组和对照组,每组40例,观察组采用盐酸羟考酮控释片进行治疗,对照组硫酸吗啡片缓释片进行治疗,对两组患者治疗前后进行痛感以及生活质量评价.结果：经过14d 的治疗后,观察组的显效率以及总有效率分别为95%和97.5%,对照组的显效率以及总有效率分别为92.5%和97.5%,两组的显效率以及总有效率相比较无显著差异(χ2=0.21,P >0.05；χ2=0,P >0.05)；两组患者治疗后与治疗前相比具有显著差异(P <0.05),两组治疗后生活质量评分相比较无显著差异(P >0.05)；两组患者不良反应主要为便秘、头晕、恶心、呕吐、嗜睡等,且观察组便秘明显较轻(P <0.01),其他不良反应两组比较差异无统计学意义(P>0.05).结论盐酸羟考酮控释片与硫酸吗啡缓/控释片治疗中重度癌痛镇痛临床效果均显著,两种药物的不良反应均较小,但羟考酮控释片的便秘发生情况较轻,在治疗中重度癌痛可以作为首选药物.
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