Radiation risks associated with serial imaging in colorectal cancer patients:Should we worry?

摘要

To provide an overview of the radiation related cancer risk associated with multiple computed tomographic scans required for follow up in colorectal cancer patients.A literature search of the PubMed and Cochrane Library databases was carried out and limited to the last 10 years from December 2012.Inclusion criteria were studies where computed tomographic scans or radiation from other medical imaging modalities were used and the risks associated with ionizing radiation reported.Thirty-six studies were included for appraisal with no randomized controlled trials.Thirty-four of the thirty-six studies showed a positive association between medical imaging radiation and increased risk of cancer.The radiation dose absorbed and cancer risk was greater in children and young adults than in older patients.Most studies included in the review used a linear,nothreshold model to calculate cancer risks and this may not be applicable at low radiation doses.Many studies are retrospective and ensuring complete follow up on thousands of patients is difficult.There was a minor increased risk of cancer from ionizing radiation in medical imaging studies.The radiation risks of low dose exposure(<50 milli-Sieverts)are uncertain.A clinically justified scan in the context of colorectal cancer is likely to provide more benefits than harm but current guidelines for patient follow up will need to be revised to accommodate a more aggressive approach to treating metastatic disease.