We present 2 cases of acute acalculous cholecystitis,an extremely rare entity in newborns. A number of risk factors have been identified,such as inspissated bile,prematurity,sepsis,dehydration,total parenteral nutrition,medications,and Escherichia coli lipopolysaccharide endotoxin. In our cases,gallbladder bile had positive bacterial cultures for E coli. We present the cases of a premature infant and a term neonate who developed acute acalculous cholecystitis:one with several risk factors and the second with a very atypical presentation.
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