Objective: To determine the prevalence of ibuprofen-sensitive asthma in schoo l-aged children with mild ormoderate persistent asthma. Study design: A randomi zed, double-blind, placebocontrolled, crossover bronchoprovocation challenge st udy in children 6 to 18 years of age with mild or moderate persistent asthma. Pa tients received a single dose of ibuprofen or placebo, per randomization, and th en returned 2 to 7 days later to repeat the procedures after taking that study d rug not received at the first visit. At each visit, patients performed spirometr y before and 1/2, 1, 2, and 4 hours after administration of study drug. We defin ed bronchospasm as a ≥20%decrease from baseline in the forced expired volume i n the first second (FEV1) and ibuprofen sensitivity as bronchospasm following ad ministration of ibuprofen but not placebo. Results: Of the 127 patients screened , 100 (mean age, 11 years) completed the study. Two patients met criteria for ib uprofen-sensitive asthma, resulting in a prevalence of 2%(95%CI: 0.2%-7%). Neither patient was known to have had any exposure to ibuprofen before the stud y. Conclusion: The prevalence of ibuprofen-sensitive asthma was low but non-ze ro in this group of children with mild or moderate asthma. The possibility of ib uprofen-induced bronchospasm should be considered before administering ibuprofen to children with asthma.
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