Objective: The following study was conducted to determine which FSH, recombinant or urinary, works better in older women. Design: We conducted a controlled randomized study in a single university IVF center. Setting: University IVF center. Patient(s): Women (N = 257) over 39 years old undergoing IVF. Intervention(s): The patients were randomized into two study groups at their first IVF cycle: 121 patients were treated with recombinant FSH, and 120 patients were treated with urinary FSH. Both groups were suppressed with a long GnRH analog protocol. Main Outcome Measure(s): Days of stimulation, E2 at the day of hCG, total amount of FSH administered, number of oocytes collected, amount of FSH per oocyte, and number of embryos obtained. Result(s): Patients treated with urinary FSH required a significantly lower total amount of FSH, and a lower amount of FSH per oocyte than women treated with recombinant FSH. The other measures evaluated did not show any statistically significant differences. Conclusion(s): Our study showed that urinary FSH performed better in older women than recombinant FSH when associated with the long protocol.
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