Objective: To study the regulation effects of Huoxue Shutong Mixture on blood lipid. Methods: The hyperlipidemia model of mouse established by ig high fat emulsion had the serum content of TC, TG, LDL-C, HDL-C detected. We used subcutaneous injection of adrenaline and ice bath to establish the rat model of acute blood stasis, and determined whole blood high cutting, middle and low shear viscosity, plasma viscosity, whole blood reduction viscosity and hematocrit. Rats with ig 12 days had the platelet aggregation rate of 1. 5 min and the maximal aggregation rate determined. Results: The high dose group of Huoxue Shutong Mixture can decrease the serum content of TC, TG, LDL-C, increase the content of HDL-C, reduce whole blood high, medium, low viscosity, plasma viscosity, blood hematocrit viscosity and the platelet aggregation rate of 1.5 min, and the maximal aggregation rate. Conclusion: Huoxue Shutong Mixture can regulate blood lipid.%目的:研究活血舒通合剂对血脂的调节作用.方法:采用小鼠ig给予高脂乳剂法建立高脂血症模型,检测血清TC、TG、LDL-C、HDL-C含量.采用大鼠皮下注射肾上腺素和冰浴法建立急性血瘀模型,检测全血高切、中切、低切黏度,血浆黏度、全血还原黏度、红细胞压积.采用大鼠ig 12天,测定血小板1min、5min的聚集率和最大聚集率.结果:活血舒通合剂高剂量组能降低血清TC、TG、LDL-C含量和升高HDL-C含量;降低全血高切、中切、低切黏度,血浆黏度、全血还原黏度、红细胞压积;降低血小板1min、5min的聚集率和最大聚集率.结论:活血舒通合剂具有调节血脂的作用.
展开▼
