健脾消积汤治疗癌因性疲乏对患者生活质量的影响

摘要

Objective: To observe effect of Jianpi Xiaoji Decoction on life quality of patients with cancer - related fatigue. Methods: Sixty - two patients were randomized to treatment group ( n = 32 ) and control group ( n = 30 ), both groups received radiotherapy for 2 treatment periods, 21 days per period. The control group took Jianpi Xiaoji Decoction for the same treatment period. After treatment, EORTC - QLQ - SF - 36 was used to evaluate fatigue conditions and adverse event was collected. Results: According to EORTC - QLQ - SF - 3 , the treatment group was better than control group in terms of physical function, role identification, emotions, signs and symptoms and overall conditions ( P < 0. 05 ). Two group was not statistically different in terms of cognitive functions and social function ( P > 0.05 ). And treatment presented less adverse event ( P <0. 05 ). Conclusion:Jianpi Xiaoji Decoction can improve immunity functions, relieve clinical symptoms and fatigue condition, improve life quality and extend survival time.%目的:观察健脾消积汤治疗癌因性疲乏对患者生活质量的影响.方法:将62例患者随机分为治疗组32例与对照组30例,2组同型肿瘤患者采用相同的化疗方案治疗;21天为1个周期,2个周期评价疗效.治疗组加用健脾消积汤治疗;21天为1个疗程,2个疗程评价疗效.观察2组治疗前后生活质量量表EORTC-QLQ-SF-36调查问卷评价、疲乏状况变化及不良反应.结果:2组生活质量量表EORTC-QLQ-SF-36问卷评分比较,治疗组躯体功能、角色功能、情绪功能、物理症状及整体状况均优于对照组,差异有统计学意义(P<0.05);而认知功能、社会功能差异无统计学意义(P>0.05).2组疲乏状况比较,治疗组疲乏状况有明显减轻,对照组无变化;治疗组优于对照组(P<0.05).不良反应比较,治疗组低于对照组(P<0.05).结论:健脾消积汤具有提高机体免疫功能,改善患者临床症状及疲乏状况,提高生活质量,延长生存期.