Objective: To observe the efficacy of the yin - nourishing and heat - clearing therapy on Polycystic ovary syndrome (PCOS ) with pattern of internal heat due to yin deficiency. Methods: Sixty patients with PCOS were randomly divided into treatment group ( n = 30 ) and control gronps( n = 30). Patients in treatment group received Ziyin Tiaoxne decoction twice daily,given orally for 25 days, and patients in treatment group received Diane -35 for 21 days. The 2 groups were treated for 3 menstrual cycles. Menstruation ( includes menstrual cycle, days, amount and texture of menses ), gestation, acne, polycystic ovaries and LH/FSH of the 2 groups were evaluated before and after treatment. Results; After 3 menstrual cycles of treatment, there was a significant difference in the resume of regular menstruation, pregnancy rate and improvement of polycystic ovaries between the two groups (P< 0.05 ). The reduction rate of acne was 92. 3% in treatment group and 90. 91 % in control group ( P <0. 05 ). All the level of LH/FSH of the 2 groups were lowered after the treatment (P< 0.05 ), but it has no significant difference among the 2 gronps(P>0.05 ). Conclusion: The yin - nourishing and heat - clearing therapy is effective for PCOS caused by deficiency of liver and kidney and pattern of internal heat due to yin deficiency. It can resume menstruation, restore ovuldation, relieve acne and promote pregnancy rate. In addition, Ziyin Tiaoxne decoction has greater safety and no adverse reactions.%目的:观察滋阴清热法治疗阴虚内热证多囊卵巢综合征的临床疗效.方法:选取60例该病患者,随机分为2组.治疗组30例,予滋阴调血汤口服,每日1剂,分两次服用,服25d,停药5d,共服3个月经周期.对照组30例,予达英-35,每日1粒,共服21d,待撤药出血后第5d重复,共服3个月经周期.观察2组患者治疗后月经改善情况、妊娠情况、痤疮改善情况,B超卵巢多囊样变改善情况,LH/FSH值改善情况.结果:治疗后,治疗组月经改善有效率86.67%,妊娠有效率75%,多囊样变改善有效率83.33%;对照组月经改善有效率70%,妊娠有效率21.42%,多囊样变改善有效率50%.2组比较均有统计学意义(P<0.05).治疗组痤疮改善有效率92.3%,对照组痤疮改善率90.91%,2组比较无统计学意义(P>0.05).LH/FSH值改善情况,2组治疗后较治疗前均有改善(P<0.05),2组间比较无统计学意义(P>0.05).结论:滋阴清热法治疗肝肾不足,阴虚内热证PCOS有明显的临床疗效,可使月经情况改善,恢复排卵,减少痤疮,促进妊娠,未发现不良反应.
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