中医治疗肝癌常用中药用药规律的文献分析

摘要

目的：探讨中药治疗肝癌的用药规律，为肝癌临床治疗及新药研发提供参考。方法：搜集2002-2012年公开发表的中文临床与实验研究文献，运用频数统计法进行统计分析。结果：临床文献中所用中药频次由高到低的是白术，黄芪，茯苓，柴胡，甘草等；实验研究文献所用中药频次由高到低的是黄芪，半枝莲，白花蛇舌草，甘草，茯苓等。临床用药两两配伍的频次由高到低是白术配伍茯苓、白术配伍黄芪、黄芪配伍党参、黄芪配伍当归、黄芪配伍茯苓等。常用药物类别主要为补虚药，其他常用类别为清热解毒药、活血化瘀药、理气药、利水渗湿药、消食药等。结论：治疗肝癌中医用药有一定的规律，主要以补虚药为主，配伍清热解毒、活血化瘀药，同时结合辨证的具体情况配伍其他类别的中药。%Objective:To investigate the medication rule of traditional Chinese medicine for treatment of liver cancer .Methods: Data-base of scientific papers published between 2002-2012 on TCM treatment of liver cancer was set up and analyzed by Frequency method . Results:The herbs mostly common used in clinical practice are Rhizoma Atractylodis Macrocephalae , Astragalus membranaceus , Poria cocos, Radix bupleuri, Liquorice.The single medicine mostly commonly experimented in labs are Macrocephalae , Sculellaria barbata, Oldenlandia diffusa , Liquorice, Poria cocos.The commonly used medicine pairs are Rhizoma Atractylodis Macrocephalae with Poria co-cos , Rhizoma Atractylodis Macrocephalae with Astragalus membranaceus , Astragalus membranaceus with Pilosulae , Astragalus membra-naceus with Angelica sinensis , Astragalus membranaceus with Poria cocos .These herbal medicines are used mainly for tonifying Qi , or for clearing heat antitoxicant , or promoting blood-activating and removing stasis , or regulating qi , diuresis or diffusing dampness , diges-tion.Conclusion:There are certain prescription rules when treating liver cancer with TCM:Most commonly used medicine is tonifying medicine , in combination with heat-clearing antitoxicant medicine and blood-activating medicine .Based on result of syndrome differenti-ation, other categories of Chinese traditional medicine can be used .