目的：评价清肺承气颗粒对大肠腑实证合并ALI/ARDS患者的肺功能和肠功能的影响，以及肠功能与肺功能之间的相关性。方法：采用前瞻性、多中心、随机、双盲、对照的实验设计方法，从2009年8月至2013年7月，在5个中心入选符合大肠腑实证表现的腹部疾患合并肺损伤的患者207例。随机分为西医常规治疗对照组、通里攻下治疗组。对照组给予西医常规综合治疗，通里攻下治疗组在对照组基础上加用通里攻下药物清肺承气颗粒。观察两组患者治疗前、治疗1d、3d、7d的氧合指数、L/M，治疗前、治疗后7 d的APACHEⅡ评分，治疗7 d后病死率。结论：清肺承气颗粒治疗大肠腑实证表现的腹部疾患所致肺损害患者，能改善患者的氧合指数、肠屏障功能，降低病死率，并证实肺功能的改善与肠功能的改善密切相关，通过治疗作用证实了“肺与大肠相表里”的密切关系。%Objective:To evaluate the effect of Qingfeichengqi granules on the lung and bowel function of patients with bowel repletion and ALI/ARDS, as well as the relevance between the lung function and bowel function .Methods: A prospective, multi-center, ran-dom, double minded and controlled trial was conducted .Two hundred and seven patients who had abdominal diseases manifested with yangming bowel repletion and lung damage treated in the 5 centers from August 2009 to July 2013 were include and randomly divided in-to treatment group and control group .Patients in the treatment group were given conventional western medicine treatment , and treatment group gave patients extra application of Qingfeichengqi granules .The oxygen index , L/M, APACHE II score before treatment and 7 days after treatment, as well as mortality rate after 7days of treatment were observed .Conclusion:Qingfeichegnqi granules treating patients with abdominal diseases manifested with yangming bowel repletion and lung damage can improve the oxygen rate and bowel function , de-crease mortality , and verify the close relevance between lung function and bowel function so that prove the “exterior-interior relation be-tween lung and large intestine”.
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