联合用药对阻络型类风湿关节炎的治疗分析

摘要

Objective:To assess clinical effectiveness and adverse effect of integrated application of TCM in treating Rheumatoid Arthri -tis( RA) of retention of dampness-heat in channel type .Methods: A total amount of 60 RA patients admitted in our hospital from De-cember 2010 to December 2012 were divided into observation group and control group according to a double-blind randomized controlled trial design method , with 30 cases in each group .Patients in the observation group were treated with Tripterygium Wilfordii and Wangbi granule , while control group applied oral hulisan capsule and compound fengshining .Comparison was made in terms of the clinical thera-peutic effect after 4 weeks and 8 weeks of treatment , the time of morning stiffness , joint pain index , swelling index , rheumatoid factor negative and adverse reaction before and after treatment .Results:After 4 and 8 weeks of treatment , the total effective rates of the obser-vation group were 83.3%and 90%, and those of the control group were 80% and 86.7%( P>0.05; the rheumatoid factor negative rate of the two groups were 76.7%and 70%(P>0.05);before and after treatment, the differences of morning stiff joints time , tender-ness index, swelling index were not obvious (P>0.05);the occurrence rate of adverse reactions in the observation group was 6.67%, while that in the control group was 30%, and there was a significant difference between the two groups ( P<0.05 ) .Conclusion: The comprehensive effect of applying different medication treatment of obstruction of collaterals type in rheumatoid arthritis is not obviously different, but the occurrence of complications is different .%目的：在辨病和辨证相结合的基础上，提出类风湿关节炎（ Rheumatoid Arthritis ，RA）的治疗原则，探讨不同中药联合治疗阻络型RA的疗效情况。方法：选取我院2010年12月至2012年12月收治的60例RA患者按照随机双盲对照试验设计方法将患者分为治疗组和对照组，每组30例。治疗组口服雷公藤多甙片和尪痹颗粒，对照组口服虎力散胶囊和复方风湿宁。比较治疗4周、8周后的临床疗效及治疗前、后关节的晨僵时间、压痛指数、肿胀指数、类风湿因子转阴情况及不良反应。结果：两组患者治疗4周、8周后，治疗组总有效率分别为83.3％、90.0％，对照组为80.0％和86.7％（ P＞0.05）；两组类风湿因子转阴率分别为76.7％和70.0％（P＞0.05）；且两组治疗前、后关节的晨僵时间、压痛指数、肿胀指数差别都不明显（P＞0.05）；而在不良反应方面，治疗组为6.67％，对照组为30.00％，两组比较，差异有统计学意义（P＜0.05）。结论：不同联合用药方式治疗阻络型类风湿关节炎的综合疗效差别不明显，但药物不良反应的发生有不同。