补肾活血法对单纯收缩期高血压大鼠 NO、AngⅡ的影响

摘要

目的：探讨补肾活血法对单纯收缩期高血压（ Isolated Systolic Hypertension ，ISH）模型大鼠血管重塑的影响。方法：采用法华林和维生素K诱导动脉中层钙化法（ WVK）法复制ISH大鼠模型，分为补肾活血汤组、氨氯地平组、补肾活血汤与氨氯地平联用组（两药联用组）、空白对照组、模型对照组，予以相应的药物干预，8周后检测大鼠尾端血压、血清一氧化氮（ Nitrogen Monox-ide，NO）、血管紧张素Ⅱ（ Angiotensin Ⅱ，AngⅡ）水平。结果：补肾活血法能够增加ISH大鼠血清NO水平，降低AngⅡ水平，较模型组均有统计学意义（ P＜0.05），且中西药联用组效果更明显。结论：补肾活血法等够改善ISH大鼠的血管顺应性。%Objective:To explore effect of the Bushen Huoxue method on vascular remodeling of isolated systolic hypertension ( ISH) rats.Methods:ISH rats model was established by WVK method , divided into Bushen Huoxue decoction group , amlodipine group, Bush-en Huoxue decoction-amlodipine combination group , blank control group , and model control group , gave corresponding drug interven-tion, measured rat’s tail blood pressure, serum NO level, AngⅡlevel after 8-week treatment.Results:Bushen Huoxue decoction can significantly increase serum NO level and reduce the AngⅡlevel in ISH rats compared with model group (P<0.05).The Chinese and western medicine combination group was more effective .Conclusion:Bushen Huoxue method can improve vascular compliance in rats of isolated systolic hypertension .