复方二至天癸颗粒对IVF准备周期子宫内膜Galectin-3的影响研究

摘要

Objective:Observe the effect of Erzhi Tiangui granule on IVF-ET ( IVF-ET) in preparing the endometrium period ga-lectin-3 ( Galectin-3 ) , and its mechanism in improving the endometrial receptivity and increasing the possibility of pregnancy . Methods:Patients in vitro fertilization-embryo transfer ( IVF-ET) preparation cycle were randomly divided into two groups ,with 31 cases in the treatment group and 31 patients in the control group .The control group was given Liuwei Dihuang pills for cycles ,and the treatment group was given Erzhi Tiangui granules for the same period .On the second cycle of menstruation ,the 21 st day,ex-tract a small amount of endometrial for detection of Galectin-3.At the same time,evaluate the kidney qi deficiency score and con-ceive rate of the two groups .Results:Kidney deficiency in both groups of patients were improved and treatment group more signifi -cantly (P<0.05).Galectin-3 expression in the treatment group also improved more obvious than that of the control group (P<0.05).As to clinical pregnancy rate,the treatment group performed better than the control group (P<0.05).Conclusion:Erzhi TianGui granules can improve patient′s clinical pregnancy rate in IVF cycle .This may relate to its enhancement of the expression of Galectin-3 in the endometrium and endometrial immune suppression .%目的:观察复方二至天癸颗粒对体外受精-胚胎移植(IVF-ET)准备周期子宫内膜半乳糖凝集素-3(Galectin-3)表达的影响,从而改善子宫内膜容受性,提高妊娠率的可能机制.方法:按随机数字表法将进入体外受精-胚胎移植(IVF-ET)准备周期的不孕患者分为2组,治疗组31例,对照组31例,分别予复方二至天癸颗粒、复方六味地黄颗粒预处理2个周期,并在第二周期月经第21天,吸取内膜组织少许,检测Galectin-3;同时分别对2组患者肾气阴两虚证候积分变化、临床妊娠率进行评定.结果:2组患者肾虚症候均有改善,治疗组改善更加明显(P