玉液汤治疗2型糖尿病的Meta分析

摘要

目的:系统评价玉液汤治疗2型糖尿病的临床疗效,为临床治疗提供循证依据.方法:通过计算机检索Pubmed、CNKI、VIP、万方医学网收集运用玉液汤临床文献,时间限制为建库至2014年9月1日,提取资料进行质量评价后,采用RevMan5.3软件进行meta分析.结果:共纳入9个RCT,共756名患者.Meta分析结果显示:运用玉液汤治疗后患者糖尿病的症状、体征、血糖改善的显效性(OR=1.97,95%CI:1.46~2.66,Z=4.46,P<0.00001)、总有效率(OR=4.82,95%CI:3.06~7.59,Z=6.78,P<0.00001),均显著优于对照组,2组比较差异有统计学意义.结论:玉液汤治疗2型糖尿病有效.上述结论尚待进一步开展更多大样本、高质量研究予以证实.%Objective:To evaluate the clinical effect of Yuye decoction in the treatment of type 2 diabetes with an attempt to provide evidences for the clinical treatment.Methods:Major online databases including PUBMED,CNKI,VIPand Wan Fang medical network were searched for a period between the time that the database were built to 2014 09 01 to collect RCT studies on Yuye decoction in treatment of type 2 diabetes.Data were extracted for quality evaluation and analyzed by RevMan 5.3 software.Results:Nine RCT trials were included.A total of 756 subjects were enrolled.The meta-analysis showed that applying Yuye decoction in treatment of type 2 diabetes had effective value in improving symptoms and signs 〔R=1.97,95%CI:1.46~2.66,Z=4.46,P<0.00001〕total effective rate 〔OR=4.8295%CI:7.59~3.06Z=6.78P0.00001〕which were remarkably higher than those of the control groupswith significant difference between control groups.Conclusion:Yuye Decoction was effective in the treatment of type 2 diabetes mellitus.The above conclusions still need further study in carrying out more large samples and confirming high quality studies.