益肺肾化痰瘀法治疗慢性阻塞性肺疾病急性加重期的疗效

摘要

Objective:To explore the curative effect of replenishing the lung and kidney and resolving phlegm and blood stasis method in treating acute exacerbation of chronic obstructive pulmonary disease .Methods:A total of 100 cases of patients with acute exacerbation of chronic obstructive pulmonary disease in our hospital from February 2016 to September 2017 were randomly divided into observation group and control group , with 50 cases in each group.The control group was treated with western medicine , and the observation group was added replenishing the lung and kidney and resolving phlegm and blood stasis method .The treatment effect of two groups was compared.Results:The observation group was superior to the control group , and the difference was statisti-cally significant ( P＜0.05) in the comparison between the two groups of patients before and after treatment , TCM syndrome, FEV1%, FEV1/FVC/%.Before treatment, the serum il-10, il-13, il-18, tnf-alpha and CRP content of the two groups were rela-tively small, with no statistical significance (P＞0.05).After treatment, the content of serum il-13, il-18, TNF-alpha and C RP decreased significantly , and the content of il-10 was significantly increased , and the difference was statistically significant ( P＜0.05).There were statistically significant differences between groups (P＜0.05).Conclusion:For the use of traditional Chinese medicine of replenishing the lung and kidney and resolving phlegm and blood stasis method , and combined western medicine , can achieve a good therapeutic effect on the patients with acute exacerbation of chronic obstructive pulmonary disease , and has a cer-tain effect on improving the therapeutic effect and improving the living standard.%目的:探讨益肺肾化痰瘀法治疗慢性阻塞性肺疾病急性加重期的疗效.方法:选取2016年2月至2017年9月北京王府中西医结合医院收治的慢性阻塞性肺疾病加重患者100例,随机分为观察组和对照组,每组50例,其中对照组采取西医治疗方式,观察组在对照组的基础上给予益肺肾化痰瘀法,比较2 组的治疗效果.结果:观察组临床总有效率为98%,显著高于对照组的76%,差异有统计学意义(P＜0.05)2组在治疗前中医证候积分差异无统计学意义(P＞0.05);治疗后2组的中医证候积分均得到了显著的改善,观察组中医证候积分明显低于对照组,差异有统计学意义(P＜0.05).2组在治疗前FEV1、FEV1/FVC差异无统计学意义(P＞0.05);治疗后2组的FEV1、FEV1/FVC/均得到了显著的改善,但中,观察组FEV1、FEV1/FVC/明显高于对照组,2组在治疗后FEV1、FEV1/FVC/方面比较,差异有统计学意义(P＜0.05).2组在治疗前,其血清IL-10,IL-13,IL-18,TNF-α和CRP差异无统计学意义(P＞0.05). 2组在治疗后,血清IL-13,IL-18, TNF-α和CRP明显降低,IL-10显著增加,差异有统计学意义( P＜0.05).结论:使用中医的补肺益肾、祛痰化瘀方法,和西医的医治方法相结合,可对患者的慢阻肺急性加重期取得良好的治疗效果,对改善治疗效果有一定的作用.