加味四妙丸辅助西药对急性痛风性关节炎患者关节肿痛症状及血生化指标的影响

摘要

Objective:To study the effects of Jiawei Simiao Pill with Western medicine on the symptoms of joint swelling and pain and blood biochemical indexes in patients with acute gouty arthritis.Methods:A total of 60 cases of acute gouty arthritis who were admitted to our hospital from January 2014 to January 2017 were selected and randomly divided into study group and control group , with 30 cases in each group.The control group was treated with Diclofenac Sodium Sustained Release Tablets and Sodium Bicarbon -ate Tablets,while the study group was additionally treated with the Jiawei Simiao Pill with the course of 3 days.The clinical effects of 2 groups,the symptoms of joint swelling and pain and the changes of blood biochemical indexes before and after 3 days treatment were compared,and the occurrence of adverse reactions was observed.Results:The total effective rate of treatment in the study group was 96.67%,which was significantly higher than 80.00% of the control group(P＜0.05).After the treatment of 3 d,the joint pain score,joint pressure pain score and joint swelling score of 2 groups were decreased significantly ,and the study group was lower than that of the control group (P＜0.05).After the treatment of 3 d,the blood uric acid,erythrocyte sedimentation rate and C reactive protein(CRP)in the 2 groups were significantly decreased ,and the study group was lower than that of the control group (P＜0.05).There were no significant differences in the incidence of dizziness ,nausea,vomiting and diarrhea between the study group and the control group(P＞0.05).Conclusion:Jiawei Simiao Pill with western medicine in the treatment of acute gouty arthritis has obvious curative effects ,and effectively improve the symptoms of joint swelling and pain and the level of blood uric acid and eryth -rocyte sedimentation rate.It is safe and worthy of clinical application.%目的:研究加味四妙丸辅助西药对急性痛风性关节炎患者关节肿痛症状及血生化指标的影响.方法:选取2014年1月至2017年1月中山市中医院收治的急性痛风性关节炎患者60例,以随机数字表法分成观察组和对照组,每组30例.对照组采用双氯芬酸钠缓释片与碳酸氢钠片治疗,观察组则在对照组的基础上联合加味四妙丸辅助治疗,治疗疗程均为3 d.分别比较2组临床疗效,治疗前、治疗3 d后关节肿痛症状及血生化指标变化情况,观察治疗期间2组不良反应发生情况.结果:观察组治疗总有效率为96.67%,明显高于对照组的80.00%(P＜0.05).治疗3 d后,2组关节疼痛评分、关节压痛评分以及关节肿胀评分显著降低,且观察组低于对照组(P＜0.05).治疗3 d后,2组血尿酸、红细胞沉降率、C反应蛋白(CRP)均显著降低,且观察组低于对照组(P＜0.05).观察组与对照组头晕、恶心呕吐、腹泻发生情况比较,差异无统计学意义(P＞0.05).结论:加味四妙丸辅助西药治疗急性痛风性关节炎疗效明显,且有效改善患者关节肿痛症状及血尿酸、红细胞沉降率,安全性较好.