四妙丸加减对痛风性关节炎的治疗效果及对实验室指标的影响

摘要

Objective:To explore the effect of simiao pills addition and subtraction on gouty arthritis and its influence on laboratory indexes.Methods:A total of 98 patients with gouty arthritis treated in our hospital were acted as the study objectives ,and were di－vided into the observation group and the control group ,according to the random digital table method ,each group with 49 cases.The control group was treated with conventional western medicine ,and observation group was treated with simiao pills addition and sub－traction on the basis of the control group ,and 2 groups were treated for 1 month continuously.The clinical efficacy of 2 groups was statisticsed and the traditional Chinese medicine (TCM) syndrome scores and related laboratory indexes of 2 groups were compared before and after treatment.Results:The total effective rate of observation group was 89.80%,which was significantly higher than the 79.59%of control group ( P＜0.05); compared with that before treatment.TCM syndrome scores of 2 groups such as joint pain,swelling,redness,joint function limitation and systemic symptoms significantly decreased after treatment (P＜0.01),and ob－servation group was significantly lower than control group (P＜0.05 or P＜0.01); compared with before treatment,the serum IL－6,IL－8,CRP,TNF－αand the whole blood BUA,ESR and WBC levels of 2 groups decreased after treatment (P＜0.01),and obser－vation group was significantly lower than control group (P＜0.05 or P＜0.01).Conclusion:Simiao pills addition and subtraction in the treatment of gouty arthritis can reduce the levels of inflammatory factors and related laboratory indexes ,significantly alleviate the joint symptoms of the patients ,and the clinical effect is better than that of western medicine alone.%目的:探讨四妙丸加减对痛风性关节炎的治疗效果及对实验室指标的影响.方法:选取2014年12月至2017年8月延安市人民医院收治的痛风性关节炎患者98例为研究对象,根据随机数字表法随机分为观察组和对照组,每组49例.对照组采用常规西药治疗,观察组在对照组的基础上采用四妙丸加减方治疗,2组均连续治疗1个月.统计2组患者临床疗效;比较治疗前后2组中医证候积分及相关实验室指标.结果:治疗后观察组的总有效率为89.80%,显著高于对照组的79.59%(P＜0.05);与治疗前比较,治疗后2组关节疼痛、肿胀、发红、关节功能受限及全身症状等中医证候积分均显著下降(P＜0.01),且观察组显著低于对照组(P＜0.05或P＜0.01);与治疗前比较,治疗后2 组患者血清IL－6、IL－8、CRP、TNF－α及全血BUA、ESR、WBC水平均显著下降(P＜0.01),且观察组显著低于对照组(P＜0.05或P＜0.01).结论:四妙丸加减治疗痛风性关节炎可降低患者炎性反应因子及相关实验室指标水平,显著缓解患者关节症状,临床疗效优于单用西药治疗.