Objective: To investigate the status of self-care agency and depression among patients of breast cancer with chemotherapy and to analyze the correlation between them. Methods: Totally 151 patients of breast cancer with chemotherapy were investigated with the exercise of self-care agency scale(ESCA) and self-rating depression scale(SDS). Using Pearson correlation analysis to analyze the correlation between them. Results: The overall score of the self-care agency was 108.60±11.78;31.1% of patients were at high level, 68.90% were at medium level. The incidence of depression was 78.8%. Self-care agency and depression were positive correlated with each other among patients of breast cancer with chemotherapy (γ=-0.556, P<0.01). Conclusions: Nurses should pay attention to reduce the occurrence of bad feelings to improve self-care agency among patients of breast cancer with chemotherapy.%目的：调查化疗期乳腺癌患者的自我护理能力及抑郁水平，并探讨两者的关系。方法：采用自我护理能力量表（ESCA）和自评抑郁量表（SDS）调查151名化疗期乳腺癌患者的自我护理能力与抑郁水平，并分析其相关性。结果：化疗期乳腺癌患者的自我护理能力总分为（108.60±11.78）分，31.1%的患者处于高等水平，68.90%处于中等水平；化疗期乳腺癌患者抑郁的发生率为78.8%，且抑郁水平要显著高于国内常模（P＜0.01）；自我护理能力水平与抑郁呈负相关（γ=-0.556，P<0.01）。结论：化疗期乳腺癌患者的自我护理能力与抑郁水平密切相关，这提示临床护理工作者应重视减少患者不良情绪的发生，以提高患者的自我护理能力水平。
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