信息时代广场舞对2型糖尿病患者氧化应激和胰岛素抵抗的研究

摘要

Objective:To explore the effect of open-air iftness dancing on blood glucose control, oxidative stress and insulin resistance in patients with type 2 Diabetes mellitus (T2DM). Methods: Age-sex matched 60 outpatient patients with T2DM were randomly divided into intervention group (group A) and control group (group B), then interfered for 12 weeks. Level of FBG, 2 h BG and HbAlc before and after interfere, as well as the insulin resistance index (HOMA-IR) and the level of serum 8-iso PGF2 was calculated. Results: 1, The level of FBG, 2 h BG and HbAlc in group A was lower than that in group B (7.622.10 vs. 8.313.38, 9.861.67 vs. 11.912.19, 8.420.97vs. 9.331.80, P 0.05). 2, Open-air iftness dancing were signiifcantly improved the insulin resistance in T2DM (8.931.50 vs. 9.872.87, P 0.05). 3, The level of 8-iso PGF2 in group A was lower than that of group B (2.770.67 vs. 45.100.44, P 0.05). Conclusion: Our data suggested that open-air iftness dancing might improve the blood glucose, oxidative stress and insulin resistance in patients with T2DM.%目的:探讨广场舞对2型糖尿病(type 2 Diabetes mellitus,T2DM)患者血糖、氧化应激和胰岛素抵抗(insulin resistance,IR)影响.方法:年龄、性别匹配的60例门诊T2DM患者随机分为干预组(A组)和对照组(B组)各30例,干预12周.干预前后分别行空腹血糖(fasting blood glucose,FBG)、餐后2小时血糖(2h blood glucose,2h BG)和HbAlc检测评价血糖水平;胰岛素抵抗指数(HOMA-IR)评估患者胰岛素抵抗;血8-异前列腺素F2(8-iso PGF2)水平评价患者氧化应激水平.结果:1.与对照组相比,广场舞组患者空腹/餐后血糖、HbAlc显著降低(7.622.10vs.8.313.38,9.861.67vs.11.912.19, 8.420.97vs.9.331.80,P 0.05);2.广场舞组患者血清8-iso PGF2水平较对照组显著降低(8.931.50 vs.9.872.87,P 0.05);3.广场舞能明显改善T2DM胰岛素抵抗(2.770.67vs.45.100.44, P 0.05).结论:本研究结果提示跳广场舞可改善T2DM患者血糖、氧化应激和胰岛素抵抗.