目的：对纯钛表面进行抗菌改性，以降低纯钛种植体周围炎的发生率，从而提高种植术的成功率。方法采用水相硅烷化方法，将3-（氨基丙基）三乙氧基硅烷（APS）组装在湿化学法处理的钛表面上，并将纳米银被覆在该表面上，采用X射线光电子能谱（XPS）和X射线能谱（EDX）对该改性表面理化性能进行分析，观察其对金黄色葡萄球菌和大肠杆菌的抗菌性能。结果扫描电镜观察可见，改性后的钛表面有不规则纳米银颗粒散在的附着在其表面上，XPS分析显示银的含量为6.8%。经过24h需氧培养，纳米银改性钛片对金黄色葡萄球菌的抗菌率达到94.23%，对大肠杆菌的抗菌率达95.34%。结论经过纳米银改性后的钛片具有抗菌性能。%Objective To deposit silver nanoparticles on a titanium surface to obtain antibacterial properties. To reduce the incidence of peri-implantitis, and improve the success rate of implantation. Methods A silver nanoparticle-modified titanium (Ti-nAg) surface was prepared using silanization method, and its surface was characterized by using X-ray photoelec-tron spectroscopy (XPS) and energy dispersive X-ray spectrometer (EDX). Two species of bacteria, namely, Staphylococcus aureus and Escherichia coli, were used to test the antibacterial effect of Ti-nAg surface. Results Scanning electron micro-scope (SEM) revealed that a small quantity of silver nanoparticles were deposited on the titanium surface. XPS analyses revealed that 6.8% of silver was present on the titanium surface. After 24 h of incubation, 94.23% of Staphylococcus aureus and 95.34% of Escherichia coli were killed on the Ti-nAg surface. Conclusion Results suggest that silver nanoparticle-modified titanium is a promising material with an antibacterial property that may be used as an implantable biomaterial.
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