血浆致动脉粥样硬化指数与冠心病及其危险因素的相关性分析

摘要

目的:探讨血浆致动脉粥样硬化指数(AIP)与冠状动脉粥样硬化性心脏病(冠心病)及其危险因素之间的关系.方法:收集天津市大港区油田常住人口体检资料348例,根据体检结果分为CHD组和正常对照组.记录2组年龄、性别、吸烟史、高血压或糖尿病史、体格检查及心电图、超声心动图等检查结果.根据三酰甘油和高密度脂蛋白胆固醇检测结果计算AIP.结果:冠心病组患者的年龄、男性比例、吸烟率、高血压患病率、糖尿病患病率、既往脑卒中患病率、体质指数(BMI)、收缩压、舒张压、空腹血糖、尿酸、AIP、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)均显著高于正常对照组,高密度脂蛋白胆固醇(HDL-C)低于正常对照组(P<0.05).2组总胆红素、静息心率、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)比较差异无统计学意义.AIP与年龄、BMI、收缩压、舒张压、空腹血糖、TG、TC、LDL-C、尿酸呈正相关;与HDL-C呈负相关;与静息心率无明显相关.以AIP为因变量的多元逐步回归分析示尿酸、TG、LDL-C、HDL-C均进入线性回归方程(P<0.05).结论:AIP与冠心病及其危险因素密切相关,AIP结合传统CHD危险因素能够更全面地评估CHD发生的风险.%Objective: To analyze the correlation between atherogenic index of plasma (AIP) and coronary heart disease (CHD), as well as its risk factors. Methods: Three hundred and forty-eight residents in Dagang district of Tianjin were included in this study. All participants were divided into CHD and control group according to their clinical examination. The clinical data were collected including patient age, gender, smoking history, hypertension or diabetes history, physic examination,electrocardiogram (ECG) and ultrasonic cardiogram. AIP was calculaed by the results of triglyceride (TG) and high-density lipoprotein (HDL).Results: It was found that the patient age, the percentage of male patients, smoking rate, prevalence of hypertension, prevalence of diabetes mellitus (DM), prevalence of stroke. BMI(body mass index), systolic blood pressure (SBP),diastolic blood pressure (DBP), fasting blood glucose, uric acid, AIP, low density lipoprotein cholesterol (LDL-C), total choles terol (TG) and triglyceride (TC) were significant higher in patients of CHD group than those of control group (P ＜ 0.05). But the level of HDL-C was lower in CHD group than that of control group (P ＜ 0.05). There were no significant differences in total bilirubin, resting heart rate (HR), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) between two groups. There were positive correlations between AIP and age, BMI, SBP, DBP, fasting blood glucose, TG, TC, LDL-C and uric acid. But there was negative correlation between AIP and HDL-C, and no significant correlaion with resting HR. The result of multiple stepwise regression analysis showed that uric acid, TG, HDL-C and LDL-C entered in the regression equaion (P ＜ 0.05). Conclusion: The level of AIP is strongly correlated with CHD and the risk factors. In combination with traditional CHD risk factors, AIP can provide more information for predicting the presence of CHD.