OBJECTIVE To investigate the clinical efficacy of standardized specific immunotherapy for children with allergic rhinitis complicated with bronchial asthma .METHODS A total of 86 children with allergic rhinitis complicated with bronchial asthma from July 2012-November 2013 were divided into control group (n=43) and ob-servation group (n=43),control group was received conventional medical treatment ,observation group was given a standardized specific immunotherapy on the basis of conventional therapy .RESULTS Lung function FEV 1 ,FEV1/FVC,PEF and FVC in children of observation group were superior to those in the control group ( P0.05 ) ,runny nose ,sneezing ,na-sal itching,and overall symptoms had statistically significant differences ( P <0.05 );IL-2, IFN-γin observation group were significantly higher than those in control group (t=5.79,t=2.58,P<0.05) and IL-4,IL-6 was signifi-cantly lower than these control group ( t=4.89 ,t=3.71 ,P<0.05 ).CONCLUSION Given a standardized specif-ic immunotherapy on the basis of conventional therapy to the children with allergic rhinitis complicated with bronchial asthma can significantly improve lung function and rhinitis symptoms ,which is safe and reliable and worthy of clinical popularization and application .%目的：探讨标准化特异性治疗在儿童变应性鼻炎并发支气管哮喘治疗中的临床效果。方法以2012年7月～2013年11月在我院治疗的变应性鼻炎并发支气管哮喘患儿86例为研究对象，对照组给予常规药物治疗，观察组在常规药物治疗的基础上给予标准化特异性免疫治疗。结果观察组患儿肺功能指标FEV1、FEV1／FVC、PEF及FVC显著优于对照组（P＜0．05）；治疗后两组治疗鼻炎症状中除鼻塞在两组中无统计学差异外（t＝0．37，P＞0．05），流清涕、打喷嚏、鼻痒及总体症状比较差异均有统计学意义（P＜0．05）；观察组患儿血清中 IL－2、IFN－γ要显著高于照组患儿（t＝5．79，t＝2．58，P＜0．05），IL－4、IL－6要显著低于对照组（t＝4．89，t＝3．71，P＜0．05）。结论儿童变应性鼻炎并发支气管哮喘治疗中在常规药物治疗的基础上给予标准化的免疫治疗能够显著改善患儿的肺功能及鼻炎症状，安全可靠，值得临床推广应用。
展开▼
