甲状旁腺激素的成骨机制及其对颅颌面和牙周组织再生的研究进展

摘要

对于口腔颌面部疾病导致的组织缺损，传统治疗方法大多为赝复体修复或骨移植，但其有很多弊端，如可引起感染或炎症、造成供区继发性损伤等。近年来，随着原位组织工程技术的发展，许多研究者开始尝试通过各种方法诱导缺损组织局部细胞发生迁移、增殖与分化，形成新生组织，从而实现口腔颌面部组织再生。甲状旁腺激素（ parathyroid hormone，PTH）作为唯一得到美国FDA批准的用于治疗骨质疏松的骨合成代谢药物，能够促进骨祖细胞的增殖和分化，是骨形成和骨重建过程中的一个重要调节因子。该文综述了甲状旁腺激素的成骨机制及其对颅颌面及牙周组织再生的作用。%The traditional treatments of tissue defects caused by oral and cranio-maxillofacial diseases are obturator prosthesis or bone transplantation,which have many drawbacks, such as infection and inflammation, secondary damage of the donor site, etc.In recent years,with the development of in situ tissue engineering technique,some researchers have begun to try various methods to induce cells within the local defect site to migrate,proliferate and differentiate,which may result in new tissue formation,thus achieving oral and cranio-maxillofacial tissue regeneration.Approved by the FDA, parathyroid hormone ( PTH ) is the unique bone anabolic drug for the treatment of osteoporosis,which is seen as an important regulatory factor in the process of bone formation and bone remodeling that can promote the proliferation and differentiation of bone progenitor cells.This article reviewed the mechanisms of parathyroid hormone on os-teogenesis and its impact on cranio-maxillofacial and periodontal tissue regeneration.