GDF15对成血管和成骨/破骨作用的影响及机制的研究进展

摘要

As a member of the TGF-β superfamily, GDF15 is widely distributed in mammalian tissues. Induced by multiple factors such as hypoxia, inflammation, radiation, acute injury or cancerization, GDF15 can play its role through both SMAD and non-SMAD pathways. According to the recent studies, the function of GDF15 on angiogenesis and bone metabolism are diverse under different mi-croenvironments. This article reviewed the effects of GDF15 on angiogenesis and bone metabolism under different microenvironments and its related signaling pathways.%生长分化因子15作为转化生长因子-β超家族中的一员，在人体组织中广泛表达。 GDF15可被多种因素(比如缺氧、炎症、射线、急性损伤或癌变)诱导表达，通过 SMAD通路和非 SMAD通路发挥作用。最新的研究表明，在不同微环境下， GDF15对于血管生成，骨代谢具有不同的调节作用。本文就GDF15在不同生物背景下对成骨/成血管作用的影响及其相关信号通路作一综述。