某半合成青霉素制药废水的水质指纹特性

摘要

High-concentration antibiotics are detected in surface water from time to time.There has been an increasing demand for strengthening the supervision of the antibiotic pharmaceutical wastewater.Three-dimensional fluorescence technique is known as a rapid,simple and high-sensitivity method.The three-dimensional fluorescence spectrum can display organic components and it was named as aqueous fingerprint.In this paper,three-dimensional fluorescence characteristics of a typical semi synthetic peni-cillin pharmaceutical wastewater were studied.There were totally four fluorescence peaks in the aqueous fingerprint of this wastewater,locating in excitation wavelength/emission wavelength of 360/445,255/445,275/305 and 230/300 nm respective-ly.Fluorescence peak’s intensity within certain range related linearly to the relative concentration.The possible fluorescent pol-lutants related to Peak C and Peak D might be the mixture of D-(-)-A-4-Hydroxyphenylglycine Dane Salt Methyl Potassium (pharmaceutical intermediates),Amoxicillin (pharmaceutical product)and D(-)-4-Hydroxyphenylglycine (pharmaceutical hy-drolysate).PH played an important role in the fluorescence characteristics of this wastewater.This indicated that the fluorescent organic pollutants in this wastewater might contain acid or base groups.The aqueous fingerprint technique could be used to mo-nitor the discharge of semi synthetic penicillin pharmaceutical wastewater as a novel tool.%近年来,地表水中时有抗生素检出,且浓度较高,因此加强抗生素废水的监管势在必行。三维荧光技术快速、简便且灵敏度高,可以反映有机物组成,其光谱被称为水质指纹。选取某典型半合成青霉素制药废水进行水质指纹特性研究。该废水共有4个主要水纹峰,分别位于激发波长/发射波长为360/445,255/445,275/305和230/300 nm附近。在一定浓度范围内,各峰强度与污染物浓度呈现良好的线性关系。该废水的两个峰275/305和230/300 nm可能源于产品中间体左旋对羟基苯甘氨酸邓钾盐、产品阿莫西林和水解产物左旋对羟基苯甘氨酸等。pH 对水质指纹有明显影响,这显示出某些荧光污染物可能具有酸碱基团。水质指纹能够用于该种抗生素制药废水的监测。