Objective: To evaluate the efficacy of adjuvant chemotherapy in patients with esophageal carcinoma undergoing radical surgery by meta-analysis. Methods: CBMDisc, CNKI, Pubmed databases were searched from January 1995 to June 2005. Randomized trials on comparison surgery plus adjuvant chemotherapy (S + C) and surgery alone for patients with local- ized carcinoma of esophagus were selected. RevMan 4.2 software was used for meta-analysis. Results: 7 studies were in- cluded in the meta-analysis. A total of 401 patients underwent radical surgery plus chemotherapy and 463 underwent surgery alone. Compared with surgery alone, the patients underwent S + C were significantly superior in the 3-year survival rate: the combined relative risk (RRs) of death was 0.83, 95% confidence interval (CI) was 0.71 to 0.95, P = 0.009. Conclusion: Based on the review, adjuvant chemotherapy has a benefit on the 3-year survival rate in the patients with esophageal carcinoma.
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