第一个书签之前
ABSTRACT
摘要
LIST OF ABBREVIATIONS
LIST OF TABLES
CHAPTER ONE
GENERAL INTRODUCTION
1.1.1 Objectives of the study
1.1.1.1 Main objectives
1.1.1.2 Specific objectives
1.1.2 Significance of the study
CHAPTER TWO
2.1.1 The esophagus and its surrounding structures
Figure 1: Some surrounding structures to the esoph
2.1.2 The development and incidence of esophageal
2.1.3 Diagnosis and treatment of esophageal squamo
2.1.3.1 Diagnosis of esophageal squamous cell carc
2.1.3.2.1 Surgery (Esophagectomy)
Figure 2: Photos showing the various approaches em
2.1.3.2.2 Neoadjuvant chemoradiotherapy (nCRT) and
2.1.4 Postoperative complications
2.5 Conclusion
CHAPTER THREE
Neoadjuvant Chemoradiotherapy or Chemotherapy plus
3.1 INTRODUCTION
3.2 METHODS
3.2.1 Studies Identification
3.2.2 Data Selection
3.2.3 Inclusion and Exclusion Criteria
3.2.3.1 Inclusion criteria:
3.2.3.2 Exclusion criteria:
Figure 3: PRISMA flow diagram of literature search
3.2.4 Data Extraction
3.2.5 Statistical Analysis
Statistical analysis was performed using Review ma
3.3 RESULTS
Table 1: Clinicopathologic
Table 2: Therapeutic regi
3.3.1.1 Neoadjuvant Chemoradiotherapy versus Surge
3.3.1.2 Neoadjuvant Chemoradiotherapy versus Surge
Figure 4: Overall survival in randomized studies c
3.3.1.3 Neoadjuvant Chemotherapy versus Surgery al
Figure 5: Overall survival in randomized studies c
3.3.2 Survival Analysis of Nonrandomized Studies C
3.3.2.1 Neoadjuvant Chemoradiotherapy versus Surge
3.3.2.2 Neoadjuvant Chemoradiotherapy versus Surge
Figure 6: Overall survival in nonrandomized studie
3.3.2.3 Neoadjuvant Chemotherapy versus Surgery al
Figure 7: Overall survival in nonrandomized studie
3.3.3 Survival Analysis of All Studies Comparing N
3.3.3.1 Neoadjuvant chemoradiotherapy versus Surge
3.3.3.2 Neoadjuvant chemoradiotherapy versus Surge
Figure 8: Overall survival in all studies comparin
3.3.3.3 Neoadjuvant chemotherapy versus Surgery al
Figure 9: Overall survival in all studies comparin
3.3.4 Survival Analysis of Locally Advanced Diseas
3.3.4.1 Neoadjuvant Chemoradiotherapy versus Surge
Figure 10: Overall survival for neoadjuvant chemor
3.3.4.2 Neoadjuvant Chemotherapy versus Surgery Al
3.3.5 Survival Analysis of Patients with Locally A
3.3.5.1 Neoadjuvant Chemoradiotherapy versus Surge
3.3.5.2 Neoadjuvant chemotherapy versus surgery al
3.3.6 Survival Analysis on Patients Locally Advanc
3.3.6.1 Neoadjuvant chemoradiotherapy versus surge
Figure 12: Overall survival for neoadjuvant chemor
3.3.6.2 Neoadjuvant Chemotherapy versus Surgery Al
3.3.7 Survival Analysis on Neoadjuvant Chemoradiot
3.3.7.1 Neoadjuvant Chemoradiotherapy versus Chemo
3.3.7.2 Neoadjuvant Chemoradiotherapy versus Chemo
3.3.8 Survival Analysis of Gender
3.3.8.1 Survival Analysis of Gender Neoadjuvant Ch
3.3.8.2 Survival Analysis of Gender Neoadjuvant ch
3.3.8.3 Survival Analysis of Gender Surgery alone
Figure 13: Overall survival of males versus female
Table 3: Summary of the re
3.3.9 Assessment of Publication Bias
Figure 14: Funnel plot of overall survival in rand
Figure 15: Funnel plot of overall survival in nonr
Figure 16: Funnel plot of overall survival in all
Figure 17: Funnel plot of overall survival in stud
Figure 18: Funnel plot of overall survival males v
Figure 19: Funnel plot of overall survival and dis
3.4 DISCUSSION AND CONCLUSION
CHAPTER FOUR
Clinical Study of Proportions and Treatment Modali
4.1 INTRODUCTION
4.2.1 Data Collection
4.2.2 Data Analysis
4.3 RESULTS
Table 4: Age distribution
Table 5: Gender distributi
Figure 21: Gender distribution among study partici
Figure 23: Postoperative complications among study
Table 6: Test for associat
Table 7: Tests for strengt
Table 8: Test for associat
Table 9: Test for strength
Table 10: Test for associa
Table 11: Test for associa
Table 12: Test for associa
4.4 DISCUSSION AND CONCLUSION
CHAPTER FIVE
GENERAL CONCLUSIONS AND FUTURE WORK
5.1 GENERAL CONCLUSIONS
5.2 INNOVATION AND NOVELTY
5.3 FUTURE WORK
REFERENCES
ACKNOWLEDGEMENTS
PUBLICATIONS
APPENDICES
Figure 24: Association between age and postoperati
Figure 25: Association between gender and postoper
Figure 26: Association between surgical techniques
Figure 27: Major pretreatment examinations used fo
Figure 28: Treatment modalities used for study par
Figure 29: Association between surgical techniques
Appendix VI
Table 13: Overall statisti
