Objective:The aim of our study was to investigate if common toxicities are correlated to objective response rate(ORR) in metastatic colorectal cancer(mCRC) patients treated by irinotecan based regimens.Methods:Univariate and multivariate logistic regression analyses were performed to evaluate correlations between common toxicities and binary ORR in 106 mCRC patients from a prospective cohort treated with irinotecan based regimens.Results:The most frequent severe toxicities(Grade 3/4) were as follows:neutropenia(27.4%),diarrhea(16.9%),leucopenia(12.6%),vomiting(3.2%) and thrombocytopenia(2.1%).Thrombocytosis was observed in 25(26.3%) patients.ORR was 25.3%.Thrombocytopenia(P = 0.014),line of chemotherapy(P = 0.028) and thrombocytosis(P = 0.033) were correlated with ORR in univariate analysis.In multivariate analysis,thrombocytopenia(odds ratio [OR] = 8.600,95% confidence interval [CI] = 1.705-43.385,P = 0.009) and first line chemotherapy(OR = 5.155,95% CI = 1.153-23.256,P = 0.032) positively related to ORR.Conclusion:Thrombocytopenia may be an indicator of ORR in mCRC patients treated by irinotecan plus 5-fluorouracil/capecitabine.Evidence is not strong enough to prove that irinotecan based regimens-induced diarrhea,leucopenia,neutropenia or vomiting is associated with ORR.
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