目的：比较氨磺必利和阿立哌唑口崩片治疗以阴性症状为主的精神分裂症的临床疗效和安全性。方法采用随机对照研究,将64例符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)诊断标准的以阴性症状为主的精神分裂症患者按照入组先后顺序分为氨磺必利组(研究组)和阿立哌唑口崩片组(对照组)各32例,疗程8周,采用阳性和阴性症状量表( PANSS)评定疗效,采用副反应量表( TESS)评定不良反应。结果治疗8周后,两组PANSS评分均下降(P>0.05),氨磺必利组和阿立哌唑口崩片组有效率分别为90.63%,87.5%,差异无统计学意义(P>0.05)。两组TESS评分分别为(3.98±1.03)分、(4.07±1.89)分,差异无统计学意义(P>0.05)。结论氨磺必利与阿立哌唑口崩片治疗以阴性症状为主的精神分裂症疗效相当,不良反应轻。%Objective To compare the efficacy and safety between amisulpride and aripiprazole in treatment of negative schizo-phrenia. Methods Using randomized controlled trials in this study, 64 patients diagnosed with negative schizophrenia were randomly divided into amisulpride group (study group) and aripiprazole orally disintegrating tablets group (control group). The positive and negative scale ( PANSS) was used to evaluate the efficacy, and treatment emergent side effect scale ( TESS) was used to evaluate the advese reactions. The course of treatment was eight weeks. Results PANSS(P>0. 05) scores of the two groups were both significant-ly decreased after 8 weeks, the efficacy rates of amisulpride group and aripiprazole orally disintegrating tablets group were 90. 63% and 87. 5%, which two groups showed no significant difference fromχ2 test (P>0. 05). The TESS scores of amisulpride group and aripi-prazole group were(3. 98 ± 1. 03)and(4. 07 ± 1. 89), The TESS scores of two groups also showed no significant difference by t-test (P>0. 05). Conclusion Amisulpride are as effective as Aripiprazole orally disintegrating tablets in treatment of negative schizophre-nia, and it has better clinical curative effect.
展开▼
