逍遥丸治疗利培酮所致女性精神分裂症患者高泌乳素血症的临床研究

摘要

Objective To study the clinical effect of Xiaoyao Pill on hyperprolactinemia caused by risperidone in the female schizophrenics. Methods All of 72 female with Hyperprolactinemia(serum PRL ﹥ 25ng/ ml)caused by risperidone were divided into the study group and the control group by random number table method,36 cases of each group. And all of the participants met the cri-terion of Diagnostic and Statistical Manual of Mental Disorders Fourth edition(DSM - IV). The study group was used Xiaoyao Pill,and the control group was the pill made by the flour for 6 months. The treatment effects of two groups were compared by the changes of men-struate and the level of PRL. The treatment effects of the symptoms of psychosis were evaluated by PANSS and CGIS before and at the end of 1st ,2nd ,6th month of treatment respectively. The adverse drug reactions were assessed by TESS. Results ①Compared with the control group,the levels of PRL of the study group were declined and the treatment effects were better at the 2nd month and the end of the 6th month,the differences were statistical significant(P < 0. 05). Moreover,the factor of time significantly effected on the level of PRL and the clinical efficacy(P < 0. 05). ②The scores of PANSS and CGIS were higher than pre - treatment at the end of the 2nd and the 6th month,the differences were statistical significant(P <0. 05). But the difference between two groups had no significant dif-ferent(P ﹥0. 05). ③The occurrence of adverse drug reactions of the two groups had no significant different in pre - treatment and post -treatment(P ﹥0. 05). Conclusion Xiaoyao Pill has effect on hyperprolactinemia caused by risperidone in the female schizophrenics. Furthermore,Xiaoyao Pill doesn’t effect on the symptoms of psychosis,and it doesn’t cause any adverse drug reactions.%目的：探讨逍遥丸治疗利培酮所致女性精神分裂症患者高泌乳素（PRL）血症的临床效果。方法采用随机数字表法将72例符合《精神障碍诊断与统计手册（第4版）》（DSM - IV）精神分裂症诊断标准的、服用利培酮所致高泌乳素血症（血清 PRL 水平﹥25ng/ ml）的女性精神分裂症患者分为两组各36例，研究组给予逍遥丸，对照组服用面粉制成的类药丸，共治疗6个月。通过测评患者月经症状改善状况和 PRL 水平变化比较两组患者高泌乳素血症临床疗效的差异，于治疗前和治疗后第1月末、第2月末、第6月末采用阳性和阴性症状量表（PANSS）、临床总体印象量表（CGIS）评定患者精神症状，采用副反应量表（TESS）评定药物不良反应。结果①治疗2月及6月末，与对照组比较，研究组血清 PRL 低，差异有统计学意义（P <0.05）；②治疗2月末及6月末，PANSS、CGIS 总评分均低于治疗前，差异有统计学意义（P <0.05），但两组间比较差异无统计学意义（P ﹥0.05）；③两组药物不良反应发生率比较差异无统计学意义（P ﹥0.05）。结论逍遥丸对利培酮所致女性精神分裂症患者高泌乳素血症有效，对精神分裂症临床症状无明显影响，无明显副作用。