鼠神经生长因子联合甲钴胺治疗糖尿病周围神经病变的疗效观察

摘要

Objective To observe the efficacy of the mouse nerve growth factor(NGF) combining with mecobalamin in the treatment of diabetic peripheral neuropathy (DPN). Methods 55 patients with DPN were randomly divided into two groups (A and B group) ,A group was given to NGF and mecobalamin、B group was given to mecobalamin only. Observing the clinical efficacy、the improving condition of MNCV and SNCV、the TCSS before and after curation. Results The efficacy of A group was highter than that of B group( P <0. 01), the MNCV and SNCV of A and B group become faster after curation(P < 0. 05) , the nerve conduction velocity of A group was higher than B group(P<0. 01) ,the TCSS of A and B group was lower after euration(P <0. 01) , the condition of A group was better than B group(P <0. 01). Conclusion Mouse nerve growth factor combining with mecobalamin is safe and effective to the treatment of diabetic peripheral neuropathy.%目的 观察鼠神经生长因子联合甲钴胺治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的临床疗效.方法 55例DPN患者随机分为A、B两组,A组为鼠源性神经生长因子+甲钴胺治疗组,B组为单纯甲钴胺治疗组,观察两组治疗前后的临床疗效、神经运动传导速度(MNCV)、神经感觉传导速度(SNCV)的改善情况、多伦多临床评分系统(toronto clinical scoring system,TCSS)的评分情况及不良反应发生情况.结果 A组总有效率为92.59％,高于B组53.57％,差异具有统计学意义(P＜0.01)；两组治疗前后MNCV、SNCV较治疗前均改善,差异有统计学意义(P＜0.05)；治疗后A组改善情况优于B组,差异有统计学(P＜0.01)；两组治疗前后TCSS评分均明显降低,差异有统计学意义(P＜0.01),治疗后A组改善情况优于B组,差异有统计学(P＜0.01),其中症状和感觉评分改善明显(P＜0.01),反射评分改善不明显(P＞0.05).结论 鼠神经生长因子联合甲钴胺治疗糖尿痛周围神经病变疗效确切,值得在临床上推广应用.