维持性血液透析患者微炎症状态与睡眠障碍的关系探讨

摘要

目的 通过对血液透析中心患者睡眠障碍的调查,探讨规律血液透析患者的失眠率及与微炎症状态的关系.方法 以126例透析龄≥6个月的患者为研究对象,分别采用阿森斯失眠量表(AIS)、不宁腿诊断标准量表进行评估,同时记录患者检验指标(铁蛋白、血红蛋白、尿素氮、肌酐、甲状旁腺素、C-反应蛋白),并以AIS =6为界值,将患者分为失眠和非失眠两组,对两组进行相关性分析.结果 失眠患者占总人数的30.18％；失眠组患者体内CRP水平明显升高,两组相比差异有统计学意义(P＜0.05),其余指标差异均无统计学意义.结论 维持性血液透析患者的失眠率为30.18％；血液透析患者微炎症状态与睡眠障碍密切相关,患者微炎症状态的存在可能是睡眠障碍发生的原因之一.%Objective To study the relationship between insomrania rate and micro-inflammatory state in the maintenance hemodialysis patients through the investigation of sleep disorders in those patients in our hemodialysis center. Methods This study included 126 patients who were followed-up for more than 6 months in our hemodialysis center. Athens insomnia scale (AIS) were used to assess the insomnia status of the ptients, and, the diagnosis standard of restless legs syndrome were used to diagnosis restless legs syndrome. AIS =6 as the cutoff value, divided the ptients into two groups, recorded there levels of ferritin, hemoglobin, urea nitrogen, creatinine, parathyroid hormone, C-reactive protein, then compare the laboratory indexes difference between the two groups. Results 30. 18% of the patients in this study with insomnia, C-reactive protein level of the insomnia group were higher than group without insomnia ( P ＜ 0. 05 ) , the other labortory indexes were no statistical difference between the two groups. Conclusion Insomnia rate in 30. 18% in maintenance hemodialysis patients. Micro-inflammatory state and sleep disorder in maintenance hemodialysis patients is closely related, micro-inflamatory state maybe one reason of the sleep disorders in maintenance hemodialysis patients.