Objective To evaluate the efficacy of the bedside hemoperfusion in treatment of the patients with acute severe hypnagogue poisoning. Methods 30 patients with severe hypnagogue poisoning in our department of emergency from Jan 2008 to Aug 2011 were selected and divided into the treatment group ( 17 cases) and the control group ( 13 cases) . Patients in both groups were given conventional medical treatment, patients in treatment group were given additional hemoperfusion therapy ( HP). The Glasgowcoma scale (GCS) , mean arterial pressure (MAP) , partial pressure of oxygen in artery ( PaO2) were compared before and after hemoperfusion in the treatment group. The incidence of pneumonia, the consciousness recovery time and the length of stay were also compared between two groups. Results The GCS, MAP and PaO2 after hemoperfusion were significantly higher than that before the hemoperfusion ( P < 0. 01). The incidence of pneumonia in treatment group was lower compared with the control group ( P < 0. 05 ) . In comparison with the control group, patients in treatment group needed shorter time for waking from coma and shorter time for hospitalization( P < 0. 01) . Conclusion Combined use of conventional medical treatment and hemoperfusion is an effective therapy for acute severe hypnagogue poisoning.%目的 评价床边血液灌流(HP)治疗急性重症安眠药中毒的疗效.方法 选取我院急诊科2008年1月~2011年8月间收住的急性重度安眠药中毒惠者30例分为对照组13例和治疗组17例,对照组行一般内科治疗,治疗组除内科治疗外行血液灌流.观察治疗组治疗前后格拉斯哥评分(GCS)、平均动脉压(MAP)、动脉血氧分压(P.O2)变化.同时对照分析两组患者肺部感染发生率、清醒时间、住院时问.结果 治疗组患者血液灌流后GCS、MAP、P.O2均较治疗前有所增高(P<0.01);治疗组患者肺部感染发生率较对照组下降(P<0.05),清醒时间及住院时间均较对照组缩短(P<0.01).结论 对急性重症安眠药中毒患者在内科治疗基础上行血液灌流,治疗效果显著.
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