急性胰腺炎患者炎症因子的表达差异与病情严重程度的相关性分析

摘要

目的：观察不同严重程度急性胰腺炎(acute pancreatitis,AP)患者炎症因子的差异表达与病情严重程度的相关性。方法收集我院2013年1月至2014年6月,确诊为 AP 的住院患者共计117例,分为轻、中、重度三组,分别测定其 APACHEⅡ评分,及血清 IL-1、IL-6、IL-8、TNF-α含量,分析其相关性。结果 APACHEⅡ评分：重度组>中度组>轻度组(P <0．05)；IL-1﹑ IL-6﹑ IL-8﹑ TNF-α在各组均增高,轻度组 IL-1和 IL-6与评分正相关,中度组 TNF-α与评分正相关,重度组 IL-8和 IL-6与评分负相关；轻度组 IL-1,IL-6,IL-8呈正相关,重度组 IL-6和 IL-8呈正相关,中度组未发现炎症因子存在相关性。结论不同严重程度的 AP 患者炎症因子表达及其相关性存在差异。%Objective To observe the difference of inflammatory factors in patients with pancreatitis acute(AP)and the severity of the disease. Methods From January 2013 to June 2014, a total of 117 hospitalized patients with APwere divided into three groups:light, moderate and severe. The APACHE II score and serum IL-1, IL-8, IL-6 and TNF-α were measured. Results APACHE II score:severe group > moderate group > mild group(P < 0. 05). IL-6, IL-8, TNF-α and IL-1 were increased in all groups, IL-1 and IL-6 were positively correlated with TNF-α in mild group, moderate group and IL-8 were positively correlated, IL-6 and were negatively correlated with IL-1, IL-6,, IL-8, IL-6 and IL-8 were positive. Conclusion The expression of inflam-matory factors in APpatients with different severity and their correlation were different.