咖啡酸片治疗甲亢药所致白细胞减少症疗效观察

摘要

Objective To observe the effect of oral Caffeic acid Tablets treatment of hyperthyroidism drug induced sec-ondary leukopenia clinical curative effect. Methods We selected 30 cases of oral hyperthyroidism drugs ( including methimazole and propylthiouracil) lead to secondary patients with leukopenia,Among the 20 cases of oral methimazole, 10 cases of propylthio-uracil were randomly divided into 2 groups, 15 cases in each group. Take medicine before blood was normal in hyperthyroidism, one group was given Coffee acid 0. 2, tid,The control group oral batyl alcohol 50mg, TID, VB410mg, tid,After medication,, re-view the blood white cells at 5 days, 7 days, 10 days, 14 days, respectively, to observe the improved degree. Results Oral Cof-fee acid group of white blood cell recovery time ( average 7 days) was significantly shorter than the control group ( mean 13 days, and the same time after taking the white cells in the ascending degree is obviously higher than that of control group, the total effi-ciency of two groups had significant difference ( P<0. 05 ) . Conclusion Oral Caffeic acid Tablets treatment to reduce disease curative effect of hyperthyroidism drug induced leukocyte, safety.%目的 观察口服咖啡酸片治疗甲亢药所致继发性白细胞减少症临床疗效. 方法 选取30例口服甲亢药(包括甲巯咪唑及丙硫氧嘧啶)导致继发性白细胞减少的患者,其中口服甲巯咪唑者20例,丙硫氧嘧啶者10例,随机分为2组,每组15例,服甲亢药前血常规均正常,治疗组给予咖啡酸0. 2g/次,3 次/d,对照组口服鲨肝醇50mg/次,3 次/d, VB410mg, 3次/d,分别于服药后5、7、10、14d复查血常规,观察白细胞提升程度. 结果 口服咖啡酸组白细胞恢复时间(平均7d)明显短于对照组(平均13d),并且服药后相同时间内白细胞提升程度明显大于对照组,两组总有效率差异有统计学意义(P<0. 05). 结论 口服咖啡酸片治疗甲亢药所致白细胞减少症疗效确切安全.