维持性血透对慢性肾衰患者疗效及血小板受体PAR S的影响

摘要

Objective To evaluate the effect of maintenance hemodialysis on the therapeutic effect of chronic renal failure patients and the effect of platelet receptor PARS. Methods Retrospectively,110 cases of patients with chronic renal failure treated in our hospital from August 2010 to September 2013 were divided into treatment group and control group on average according to different intervention. The control group were treated with conventional therapy and the treatment group were treated with mainte-nance hemodialysis on the basis of conventional therapy,3 times per week and 4 hours each time. Both group accepted a month of treatment. Results The effective rate of treatment group (94. 5%) was higher than that of control group (78. 2%),(P<0. 05). Blood creatinine, urea nitrogen, PAR1 and PAR4 values were lower than before in both two groups after treatment(P<0. 05) and those indexes were different between groups ( P<0. 05 ) . Conclusion Maintenance hemodialysis could effectively improve renal function treatment efficiency in patients with chronic renal failure, reduce the platelet PARS receptor level and platelet adhesion and aggregation function and improve blood coagulation function.%目的：探讨维持性血透治疗对慢性肾功能衰竭患者疗效及血小板受体PAR S的影响。方法回顾性分析2010年8月至2013年9月我院住院治疗的慢性肾功能衰竭患者110例，根据干预方法的不同分为治疗组与对照组，各55例。对照组给予常规治疗，治疗组在对照组基础上加用维持性血液透析治疗，每周透析3次，每次4h。两组治疗疗程均1月。结果治疗组有效率(94．5%)高于对照组(78．2%)，两组比较差异有统计学意义(P<0．05)。治疗后两组血肌酐、尿素氮、PAR 1和PAR 4值较治疗前均降低，差异有统计学意义( P<0．05)，同时组间对比差异有统计学意义( P<0．05)。结论维持性血透治疗能有效改善慢性肾功能衰竭患者的肾功能，提高治疗有效率，同时降低血小板PAR S受体水平，减低血小板粘附聚集功能，改善凝血功能。